André Matade Matsangaissa (1950 - October 17, 1979) was a Mozambican rebel leader and the founder and first president of the Mozambican National Resistance (RENAMO).

Born in Gorongosa, Mozambique, Matsangaissa joined FRELIMO in 1972, and after FRELIMO’s victory in 1975 he became a quartermaster stationed at Dondo, near Beira. He was punished for theft by being expelled from the Mozambican Army (Forças Armadas de Moçambique, FAM) and was placed in a re-education camp at Gorongosa. He was freed during an attack on the camp by Rhodesian forces and was taken to Rhodesia. In 1977 Matsangaissa was appointed by the Rhodesians as leader of the Mozambican National Resistance (RENAMO) in an effort to indigenize the rebel group. Matsangaissa died in a 1979 raid against FRELIMO in Sofala Province, Mozambique.